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  2. The Hill equation is expressed mathematically as $$Y = frac { [L]^n} {K_d + [L]^n}$$ where Y is the fraction of occupied binding sites, [L] is the ligand concentration, and n is the Hill coefficient indicating cooperativity.
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    The Hill equation is expressed mathematically as $$Y = frac { [L]^n} {K_d + [L]^n}$$ where Y is the fraction of occupied binding sites, [L] is the ligand concentration, and n is the Hill coefficient indicating cooperativity.
    library.fiveable.me/key-terms/biological-chemistry-i/…
    The Hill equation, which was originally formulated by Archibald Hill in 1910 to describe the sigmoidal O 2 binding curve of haemoglobin, is used to describe the fraction of a macromolecule saturated by ligand as a function of the ligand concentration.
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    Hill equation (biochemistry) - Wikipedia

    In biochemistry and pharmacology, the Hill equation refers to two closely related equations that reflect the binding of ligands to macromolecules, as a function of the ligand concentration. A ligand is "a substance that forms a complex with a biomolecule to serve a biological purpose" (ligand definition), and … See more

    The Hill equation is commonly expressed in the following ways.
    ,
    where: See more

    The Hill coefficient is a measure of ultrasensitivity (i.e. how steep is the response curve).
    The Hill coefficient, $${\displaystyle n}$$ or See more

    The Hill equation is used extensively in pharmacology to quantify the functional parameters of a drug and are also used in other areas of … See more

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    A distinction should be made between quantification of drugs binding to receptors and drugs producing responses. There may not necessarily … See more

    The most common form of the Hill equation is its irreversible form. However, when building computational models a reversible form is … See more

    Because of its assumption that ligand molecules bind to a receptor simultaneously, the Hill equation has been criticized as a physically unrealistic model. Moreover, the Hill coefficient should not be considered a reliable approximation of the number of … See more

     
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  4. Hill Equation Explained: Definition, Examples, Practice …

    The Hill Equation, developed by Archibald Hill, describes cooperative ligand binding in allosteric proteins, particularly hemoglobin. It allows for the analysis of protein-ligand interactions by transforming the fractional saturation equation …

  5. Hill Equation - Interactive Graph - PhysiologyWeb

    Oct 22, 2014 · The interactive graph provided below allows for a good understanding of the Hill equation, how the reaction velocity changes as a function of the substrate concentration, and how changes in V max, K 0.5, and …

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